Table 1.
Summary of average clinical data and flow cytometry data during ZEBOV-Makona infection.
| Days post infection | 1 | 2 | 3 | 4 | 5 | 6 |
|---|---|---|---|---|---|---|
| Number of samples | 10 | 10 | 6 | 6 | 4 | 4 |
| Viral load (genome copy/mL) | 50 | 50 | 1.89E06 | 3.12E08 | 1.37E09 | 3.68E10 |
| Body temperature (°F) | 101.1 | 100.5 | 100.8 | 103.5 | 104.95 | 104.2 |
| Rash (fraction of animals) | 2/4 | 3/4 | ||||
| Anorexia, depression (fraction of animals) | 4/4 | |||||
| Weakness (fraction of animals) | 2/4 | |||||
| Hemorrhage (fraction of animals) | 1/4 | |||||
| AST levels (U/L) (average ± SEM) | 51 ± 0.04 | 64.3 ± 0.03 | 42 ± 0.03 | 54.5 ± 0.04 | 71 ± 0.06 | 278.75* ± 0.07 |
| CRP levels (mg/L) (average ± SEM) | 7.2 ± 0.05 | 4 ± 0.07 | 4.1 ± 0.08 | 25.3* ± 0.07 | 112.1* ± 0.07 | 116.5* ± 0.11 |
| BUN levels (mg/dL) (average ± SEM) | 20 ± 1.53 | 26.5* ± 1.42 | 14.7 ± 1.48 | 13 ± 1.70 | 16 ± 2.04 | 23.5* ± 2.44 |
| Platelet levels (×103/μL) (average ± SEM) | 357 ± 0.03 | 375.8 ± 0.04 | 342 ± 0.04 | 310.5 ± 0.04 | 205* ± 0.04 | 162* ± 0.04 |
*p-value ≤ 0.05 compared to day 0; average ± standard error of predicted mean is shown.