Table 2.

Significantly dysregulated miRNAs across all group comparisons.

	miRNA	CPM (B)	CPM (A)	FC	t-test	Exact test	Wilcoxon	Error rate
Control (A) vs. RRMS (B)	15b-5p	314	145.9	2.1	0.045	0.002	0.05	0.23
	30b-5p	673	246	2.7	0.06	0.0004	0.026	0.21
	342-3p	329	132	2.4	0.05	0.0002	0.008	0.21
	451a	39592	19114	2	0.009	0.0003	0.005	0.2
Control (A) vs. S/PPMS (B)	127-3p	1,715	752	2.2	0.007	0.001	0.003	0.17
	370-3p	707	321	2.2	0.008	0.002	0.007	0.18
	409-3p	2,893	1,385	2.1	0.005	0.002	0.002	0.17
	432-5p	682	308	2.2	0.002	0.001	0.003	0.16
	15b-5p	314	135	2.3	0.04	0.008	0.05	0.23
	223-3p	2646	934	2.8	0.026	0.002	0.047	0.22
	23-3p	1116	506	2.2	0.04	0.005	0.025	0.21
S/PPMS (A) vs. RRMS (B)	30b-5p	673	219	3.1	0.05	0.001	0.015	0.20
	342-3p	329	130	2.5	0.05	0.0016	0.02	0.22
	374a-5p	328	159	2.1	0.02	0.009	0.038	0.22
	432-5p	329	682	0.5	0.004	0.006	0.005	0.19
	433-3p	195	414	0.5	0.003	0.0027	0.0007	0.14
	485-3p	295	618	0.5	0.0056	0.002	0.004	0.17

Abbreviations: CPM, miRNA counts per million; FC, fold change; RRMS, Relapsing Remitting Multiple Sclerosis; S/PPMS, Secondary/Primary Progressive Multiple Sclerosis; HC, healthy control; EDSS, expanded disability status score; NA, not applicable; Error rate, estimated by leave-one-out cross validation.