Table 2.
KEGG pathway enrichment analysis of hypoxia-regulated genes.
| Spalax | rat | ||
|---|---|---|---|
| upregulated | downregulated | upregulated | downregulated |
| circadian rhythm | metabolic pathways | metabolic pathways | metabolic pathways |
| MAPK signaling pathway | metabolism of xenobiotics by cytochrome P450 | RNA transport | RIG-I-like receptor signaling pathway |
| adipocytokine signaling pathway | drug metabolism - cytochrome P450 | glycolysis/gluconeogenesis | terpenoid backbone biosynthesis |
| insulin signaling pathway | glutathione metabolism | ribosome biogenesis in eukaryotes | cytosolic DNA-sensing pathway |
| pathways in cancer | histidine metabolism | pentose phosphate pathway | Hepatitis C |
Shown are the ‘Top Five’ KEGG pathways significantly enriched (p < 0.01) with significantly regulated genes (p < 0.01) in the two species, respectively.