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. 2017 Oct 26;7:455. doi: 10.3389/fcimb.2017.00455

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Copyright © 2017 Li, Lu, Wang, Qin, Wang, Qiu, Wu, Huang, Zhang, Shi and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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5-Fu induced the alteration of inflammatory chemokines/cytokines in colonic tissues or serum at protein and gene expression levels. (A) The alteration of inflammatory chemokines/cytokines in colonic tissure measured by protein chip analysis. (B–D) The inflammatory chemokines/cytokines gene expression measured by qPCR assay. (E,F) 5-Fu induced the alteration of inflammatory chemokines/cytokines in serum. (G,H) 5-Fu induced the alteration of inflammatory chemokines/cytokines in colonic tissues. Values were expressed as mean ± S.E.M (n = 10/group). Data were analyzed by t-test. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 vs. control group.