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. 2017 Oct 26;7:455. doi: 10.3389/fcimb.2017.00455

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Copyright © 2017 Li, Lu, Wang, Qin, Wang, Qiu, Wu, Huang, Zhang, Shi and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Disturbed gut microbiota resulted in body weight loss and colon shortening in 5-Fu treated mice. (A) Normal fecal microbiota transplantation inhibited 5-Fu induced body weight loss. Data plotted as percentage of initial body weight. (B,C) The effect of normal fecal microbiota transplantation on colon length. Values were expressed as mean ± S.E.M (n = 7/group). Data were analyzed by t-test. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 vs. 5-Fu group. (D) Fecal microbiota transplantation from 5-Fu treated mice induced body weight loss in mice pretreated with vancomycin. Data were plotted as percentage of initial body weight. (E,F) The effect of fecal microbiota transplantation from 5-Fu treated mice on colon length in vancomycin pretreated mice. Values were expressed as mean ± S.E.M (n = 10/group). Data were analyzed by t-test. ^*P < 0.05, ^**P < 0.01 vs. control group.