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. 2017 Oct 30;7:14360. doi: 10.1038/s41598-017-14307-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Leukocyte adhesion two hours following IVC ligation (lig) was reduced in pcsk9 ^−/− mice compared to WT mice (n = 4 mice per group). Adherent leukocytes were defined as leukocyte lack of movement for two-minutes and quantified by counting overlaid pictures at 0 min and 2 min. Cells at 0 minutes are green, 2 minutes are red, and cells present at both time points are yellow (A) Representative photomicrograph of leukocyte adhesion in sham-operated WT mice (upper panel), WT mice 2 hours following ligation (middle panel), and pcsk9 ^−/− mice 2 hours following ligation (lower panel). (B) Quantification of adherent leukocytes expressed as number of attached leukocytes per unit area. *P < 0.05. **P < 0.01. Scale: 50 μm. (C) Expression of CD45 in IVC 48 hours after ligation was lower in pcsk9 ^−/− mice compared to WT mice (n = 5 per group). *P < 0.05.