Table 1.

Proposed units of analysis to examine the role of pattern separation in depressive and anxiety disorders, presented in a Research Domain Criteria (RDoC) matrix format (Cuthbert and Insel, 2013).

Construct	Molecules	Cells	Circuits	Behavior	Self-Report
Pattern Separation	Mono-Unsaturated Fatty Acids Resonating at 1.28 ppm	Neurogenesis	Frontal–Hippocampal–Dentate Gyrus–Limbic System	Mnemonic Similarity Task	*BDI, AAQ, YSQ, RFQ

The RDoC was introduced by the National Institute of Mental Health as a novel research framework to study psychopathology. It integrates several units of analysis spanning from the basic genetic/molecular level to the behavioral level.

^*BDI, Beck Depression Inventory; AAQ, Acceptance and Action Questionnaire; YSQ, Young Schema Questionnaire; RFQ, Reflective Functioning Questionnaire.