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. 2017 Oct 30;7:14336. doi: 10.1038/s41598-017-14298-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ISO-1 treatment and MIF genetic depletion both reduce retinal gliosis. Immunofluorescence staining shows GFAP accumulation (green) after RD (b,c,e,f) compared with attached controls (a,d) in vehicle or ISO-1 treated animals at day 3 or day 14 (n = 6/group). Treatment with ISO-1 displayed significant reduction in gliosis in day 14 eyes (k, *p = 0.0256) while GFAP expression in day 3 detached retina was not significantly decreased (k, p = 0.1898). Detached retinas in day 14 BALB/c wild type controls (h) and MIFKO mice (j) displayed increased gliosis by GFAP accumulation over adjacent attached retina in controls (g,i). Detached retina in MIFKO mice had significantly reduced GFAP accumulation compared with background mice (l, n = 5/group, *p = 0.0319). Scale bar denotes 50 microns.