Table 3.
Susceptibilities of strains to fluoroquinolones and efflux pump substrates.
| Strain | MIC (μg/ml)a | |||||||
|---|---|---|---|---|---|---|---|---|
| LVX | LVX+Rs | CPX | CPX+Rs | EtBr | EtBr +Rs | Acr | Acr+Rs | |
| S. pneumonia R6 | 0.25 | 0.25 | 0.5 | 0.5 | 1 | 0.25 | 1 | 0.5 |
| S. pseudopneumoniae CCUG49455T | 0.25 | 0.25 | 0.5 | 0.25 | 0.5 | 0.25 | 0.5 | 0.25 |
| S. pseudopneumoniae CCUG48465 | 0.5 | 0.5 | 0.5 | 0.25 | 0.5 | 0.25 | 0.5 | 0.25 |
| S. pseudopneumoniae 5305 | 1 | 0.5 | 4 | 0.5 | 16 | 0.25 | 8 | 1 |
| S. pneumonia T5305 | 1 | 0.5 | 4 | 0.25 | 16 | 0.25 | 4 | 1 |
| S. pneumonia T5305.1 | 1 | 0.5 | 4 | 0.25 | 16 | 0.25 | 8 | 1 |
| S. pneumonia T5305.2 | 1 | 0.5 | 4 | 0.25 | 16 | 0.25 | 4 | 1 |
| S. pseudopneumoniae CipR71 | 1 | 0.5 | 4 | 0.25 | 8 | 0.25 | 4 | 1 |
| S. pneumonia TCipR71.2 | 1 | 0.5 | 4 | 0.25 | 16 | 0.25 | 4 | 1 |
a
Acr, acriflavine; CPX, ciprofloxacin; EtBr, ethidium bromide; LVX, levofloxacin; Rs, reserpine. MICs are the average of at least three determinations, which did not differ more that 2-fold dilution. Figures in bold indicate MICs at least 2 dilutions higher in the absence of reserpine than those of R6 and the S. pseudopneumoniae CCUG48465, and S. pseudopneumoniae type strain CCUG49455T.