Table 4.
Comparison of coding and regulatory sequences of S. pseudopneumoniae homologs to S. pneumoniae pumps associated to drug efflux.
| Operon or genea | Transporterb | Coding sequencec | Upstream sequenced | |||||
|---|---|---|---|---|---|---|---|---|
| Gene | % Identity | N° of simultaneous changes | %Identity (indels) | N° of simultaneous SNPs | ||||
| 5305 | CipR71 | 5305 | CipR71 | |||||
| SP0967-72 | MFS-PmrA | SP0972 | 97.3e | 100f | 0 | 100 (0) | 100 (0) | 0 |
| SP1116 | ABC | SP1116 | 95.9 | 100 | 0 | 96 (0) | 98 (0) | 0 |
| SP1166 | MATE | SP1166 | 98.9 | 98.2 | 1 | 100 (0) | 100 (0) | 0 |
| SP1359-7 | ABC-MDR1 | SP1358 | 98.3 | 100 | 0 | 95 (0) | 98 (0) | 0 |
| SP1357 | 96.6 | 98.1 | 11 | – | – | – | ||
| SP1840 | 100 | 100 | 0 | – | – | – | ||
| SP1840-39 | ABC-MDR1 | SP1839 | 99.5 | 100 | 0 | 100 (0) | 100 (0) | 0 |
| SP1919-8 | ABC | SP1919 | 98.4 | 99.3 | 2 | 96 (0) | 97 (0) | 0 |
| SP1939 | 96.1 | 100 | 0 | – | – | – | ||
| SP1939 | MATE-DinF | SP2065 | 95.8 | 100 | 0 | 100 (0) | 100 (0) | 0 |
| SP2065 | MATE | SP2075 | 98.9 | 99.2 | 2 | 95 (0) | 100 (0) | 0 |
| SP2075-3 | ABC-MDR1-PatAB | SP2073 | 98.0 | 99.3 | 2 | 94 (1) | 95 (1) | 3 |
Loci of TIGR4 (GenBank accession number AE005672), operon indicates the genes included in the same transcriptional unit, as loaded from the DOOR database (39).
ATP binding cassette (ABC); multiantimicrobial extrusion (MATE); major facilitator superfamily (MFS).
Identities (%) in the coding sequence (amino acid residues) of the permease subunits with respect the S. pseudopneumoniae type strain ATCC BAA-960.
The sequences positions −101 to −1 of the gene/ first gene of the operon were compared. −, no applicable.
S. pseudopneumoniae 5305 has 1-30 and 325-393 deletions for this protein.
S. pseudopneumoniae CipR71 has a 80 residues insertion in the C-terminus (394-473).