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. 2017 Oct 30;7:14381. doi: 10.1038/s41598-017-14366-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DBR co-localize extensively with regions of H4 Acetylation. (A) Heat map demonstrating the level of H4 Acetylation occupancy the 1150 DBR in EPO treated cells. (B) Relationship of DBR with and without co-localization of H4Ac to known genomic features. DBR that co-localize with H4Ac are located almost exclusively near protein coding genes, in stark contrast to DBR that do not localize with H4Ac, which are distributed more evenly throughout the genome. (C) Genes in close proximity (within 10 kb) of DBRs that co-localize with H4Ac are expressed at significantly higher levels than genes in close proximity of DBR that do not co-localize with H4Ac. (D) Example of H3K4me2 and H4Ac occupancy at the IRS2 locus. Grey bar represents DBR. (E) Example of H3K4me2 and H4Ac occupancy at the KDM6B locus. Grey bar represents DBR.