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. 2017 Oct 30;7:14381. doi: 10.1038/s41598-017-14366-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptome analyses of EpoR-null and control cells. (A) Heat map of genes differentially expressed in neural tubes isolated from EpoR null and littermate control E9.0 embryos. (B) Left panel: Diseases or Functional Annotations identified through Ingenuity Pathway Analyses of differentially expressed genes. Pathways highlighted in orange include REST. Right panel: Transcription factors predicated to be upstream of genes differentially expressed between EpoR-null and littermate control neural tubes. NRF1 is the most significantly enriched transcription factor predicted to be upstream of the differentially expressed genes.