Figure 3.

BCP protects the brain against transient focal ischemia in mice. Focal brain ischemia was induced by 60 min of ischemia and 48 h of reperfusion. BCP (8, 24, 72 mg/kg/day) was administered before I/R for three consecutive days. (A) Neurological deficit scores of mice subjected to I/R in the five groups (n = 10 per group). (B) Representative photographs of TTC-stained brain sections of different groups. (C) Infarct volumes of mice brain presented as a percentage of intact hemisphere (n = 3, ^##p < 0.01 vs. sham, and ^**p < 0.01 vs. I/R). (D) H&E staining images of the hippocampal CA1 region in brain sections after I/R (n = 3). Scale bar 200 μm. (E) Representative TEM images of mitochondrial morphologic changes in the hippocampal CA1 region in the mouse brain exposed to I/R (n = 3). Scale bar 1 μm.