Table 2.
Maximal relaxation responses (%) and −logEC50 in isolated aorta arteries of 8 month-old variously treated spontaneously diabetic Goto-Kakizaki (GK) rats and age-matched non-diabetic Wistar rats.
| W | GK | GKS | GKP | GKSP | |
|---|---|---|---|---|---|
| ACh | |||||
| pEC50 | 7.59 ± 0.1 | 6.47 ± 0.18*** | 7.8 ± 0.24ϕϕϕ | 7.64 ± 0.13ϕϕϕ | 7.4 ± 0.18ϕϕ |
| Maximal relaxation (%) | 86.5 ± 3.8 | 50.7 ± 3.7*** | 63 ± 3.6***,ϕϕϕ | 63.1 ± 2.7***,ϕϕϕ | 74.3 ± 3.1 **,ϕϕϕ,§,# |
| SNP | |||||
| pEC50 | 7.7 ± 0.03 | 7.6 ± 0.03 | 7.96 ± 0.05 ***,ϕϕϕ | 7.98 ± 0.04*,ϕϕϕ | 7.9 ± 0.04*,ϕϕϕ |
| Maximal relaxation (%) | 97.1 ± 1.2 | 92.9 ± 1.4 | 98.1 ± 1.6 | 98.8 ± 1.4 | 97.5 ± 2.2 |
Data are expressed as mean±SE (n = 12 animals in each group). pEC50 values are presented as the negative logarithm (−logEC50) of concentration of the agonist.
*P < 0.05, **P < 0.01, ***P < 0.001 vs W rats.
ϕϕP < 0.01, ϕϕϕP < 0.001 vs GK rats.
§P < 0.05 vs GKS.
#P < 0.05 vs GKP.