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. 2017 Oct 30;8:1186. doi: 10.1038/s41467-017-01383-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Class IV drugs suppress the recovery of FoxO3a signaling. a–c Distribution of the nuclear/cytoplasmic ratio FoxO3a as measured by quantitative immunofluorescence microscopy at timepoints indicated. For each distribution, ~2000 cells were analyzed. Cells were treated with alpelisib in combination with either a lapatinib, b neratinib, or c trametinib at the concentrations shown. Gray line show untreated control, blue alpelisib, red the EGFR or MEK inhibitor, and black the combination treatment. Data shown is one out of three biological replicates