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. 2017 Oct 30;7:14383. doi: 10.1038/s41598-017-14596-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Rev-erb-α modulates FoxO nuclear translocation and directly regulates atrophy-related genes through a direct binding to their regulatory sequences. (A) Representative immunostaining of FoxO1 (upper panels) and FoxO3a (lower panels) in green and Dapi nuclear staining in blue of C2C12 myogenic cells treated or not with dexamethasone (1 µM) and co-treated with SR9009 (10 µM). (B) Nuclear intensity quantification of FoxO1 and FoxO3a (n > 100 cells per condition). Results are expressed as means ± s.e.m; *p < 0.05, ***p < 0.001, ****p<0.0001 by One-way ANOVA with Bonferroni post-hoc analysis. (C) Rev-erb-α binding to regulatory regions of the indicated atrophy-related genes measured by ChIP-qPCR (n ≥ 2 independent experiments). Data are expressed as means ± s.e.m.