Figure 2.

Different phenotypes of circulating neutrophils. Based on their weight, neutrophils are divided into either NDNs and LDNs. NDNs include immature neutrophils, resting neutrophils, primed neutrophils, and activated neutrophils. LDNs include immature LDNs, pro-inflammatory LDNs, immunosuppressive LDNs, and exhausted neutrophils. Immature LDNs and proinflammatory LDNs are further classified as inflammatory LDNs, whereas immunosuppressive LDNs and exhausted neutrophils are classified as suppressive LDNs. Although this illustration depicts a schematic classification of neutrophils, it is still unclear whether these are distinct neutrophil subsets.