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. 2017 Oct 30;7:14303. doi: 10.1038/s41598-017-14338-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The ICP preconcentrator-integrated sensor system. (a) The system was composed of 4 IMEs on a chip and 2 microfluidic channels for the ICP preconcentration phenomena. In a microfluidic channel, one IME was utilized for the antibody against the binding protein and the other IME was utilized for the reference electrode. (b) Image of the ICP preconcentrator-integrated sensor system with IME. (c) Scanning electron microscope image of IME. (d) Fluorescence images of Aβ preconcentration on IME, scheme of the ICP preconcentration phenomena on IME, fluorescent intensity of Aβ on IME and the location of the preconcentration plug over time. (e) Aβ antibody functionalization and BSA binding to block nonspecific binding.