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. 2017 Oct 30;7:14303. doi: 10.1038/s41598-017-14338-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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System performance with respect to Aβ detection. (a) Real-time detection of 10 pg/mL Aβ and 10 μg/mL PSA. The net signal differential was calculated between the sample and control. (b) Electrical signal versus Aβ concentration using a preconcentration step (red; squared), showing great increase in sensitivity and LOD while no significant increase in slope without a preconcentration step (Blue; open dot). Three sigma based lines of standard deviation were calculated both from mean value of 0.1 pg/mL Aβ signal. Three sigma for negative control (10 μg/mL PSA) were calculated with the standard deviation.