Description of cohort. HCC, hepatocellular carcinoma; RDS, reduced dose sorafenib; SDS, starting dose sorafenib. (*) Patients who were determined to have miscoding of their HCC ICD9 codes based on manual chart review; (†) Patients who were prescribed sorafenib but either never picked up the prescription or never ingested pills; (C)Of the 1,809 RDS patients, 134 patients (7%) had at least one missing variable and therefore could not have propensity score calculated. The remaining 1,675 RDS patients were 1:1 matched to 1,675 SDS patients.