Figure 9.

Proposed model illustrating the stabilization of catalytic active Caspa tetramers by Caiap. 1. Macrophages are recruited to the infection site where they are infected by S. Typhimurium (ST), which is contained within the Salmonella-contained vesicle (SCV). 2. Flagellin is inadvertently injected into the cytosol though the type 3 secretion system of ST where it is recognized by a Nlr. 3. The inflammasome is assembled via formation of Asc specks. 4. Active Caspa interacts with Caiap via its ANK domains and induces its self-oligomerization through CARD/CARD allowing Caspa stabilization in high molecular weight complexes upon its prodomain release.