FIGURE 3.

Effect of taurine on proliferation and migration. (A) Taurine (10 mM) enhances the fraction of BrdU positive neurons in mouse neurospheres after 4–5 days in culture, indicating that taurine promotes proliferation (^∗ indicate P < 0.05, with permission from Hernandez-Benitez et al., 2010). (B) Radial migration of RFP-labeled neurons in the substantially GABA-depleted GAD67-GFP mice can be enhanced by inhibition of GABA_A receptors with gabazine (middle image) and by inhibition of maternal taurine synthesis with D-cysteinate (D-CSA, lower image), indicating that taurine acting of GABA_A receptors modulate radial migration in vivo (modified with permission from Furukawa et al., 2014).