Table 3.
Univariate and multivariate analysis for the risk of anaplastic thyroid cancer (ATC)-related death.
| Univariate Analysis |
Multivariate analysis |
|||
|---|---|---|---|---|
| Parameter | HR (95%CI) | p | HR (95%CI) | p |
| Male gender | 0.64 (0.32–1.27) | 0.20 | ||
| Age at diagnosis | 1.08 (1.03–1.12) | 0.001 | 1.06 (1.00–1.12) | 0.05 |
| ≥70 years | 3.64 (1.70–7.80) | 0.001 | 1.13 (0.94–1.37) | 0.20 |
| Tumor size | 1.23 (1.01–1.48) | 0.036 | ||
| >6 cm | 2.85 (1.26–6.44) | 0.012 | ||
| Extrathyroid invasion | 1.91 (0.81–4.52) | 0.14 | ||
| Coexistence with differentiated thyroid cancer (DTC) | 0.45 (0.22–0.91) | 0.027 | 0.70 (0.29–1.67) | 0.42 |
| Stage IVA (n = 16) | 1.0 | |||
| Stage IVB + IVC (n = 27) | 2.01 (0.97–4.16) | 0.059 | ||
Data at univariate analysis indicate that the risk of ATC-related death increases +8% for the increase of each year of age at diagnosis and +23% for each cm of cancer size increase while it is reduced by 55% when coexisting DTC.