Table I.
Top 5 most significant upregulated and downregulated DEGs from GO analysis across 3 categories including BP, CC and MM.
| A, Upregulated DEGs | |||
|---|---|---|---|
| ID | Term | Count | P-value |
| GOTERM_BP_FAT | GO:0000279-M phase | 27 | 1.68×10−20 |
| GOTERM_BP_FAT | GO:0022403-cell cycle phase | 29 | 2.93×10−20 |
| GOTERM_BP_FAT | GO:0000280-nuclear division | 22 | 2.64×10−18 |
| GOTERM_BP_FAT | GO:0007067-mitosis | 22 | 2.64×10−18 |
| GOTERM_BP_FAT | GO:0000087-M phase of mitotic cell cycle | 22 | 3.84×10−18 |
| GOTERM_CC_FAT | GO:0005819-spindle | 10 | 4.39×10−7 |
| GOTERM_CC_FAT | GO:0000775-chromosome, centromeric region | 9 | 1.34×10−6 |
| GOTERM_CC_FAT | GO:0000793-condensed chromosome | 9 | 1.81×10−6 |
| GOTERM_CC_FAT | GO:0000777-condensed chromosome kinetochore | 7 | 1.93×10−6 |
| GOTERM_CC_FAT | GO:0000779-condensed chromosome, centromeric region | 7 | 4.16×10−6 |
| GOTERM_MF_FAT | GO:0005524-ATP binding | 27 | 1.39×10−5 |
| GOTERM_MF_FAT | GO:0030554-adenyl nucleotide binding | 28 | 1.49×10−5 |
| GOTERM_MF_FAT | GO:0032559-adenyl ribonucleotide binding | 27 | 1.76×10−5 |
| GOTERM_MF_FAT | GO:0001883-purine nucleoside binding | 28 | 1.97×10−5 |
| GOTERM_MF_FAT | GO:0001882-nucleoside binding | 28 | 2.23×10−5 |
| B, Downregulated DEGs | |||
| ID | Term | Count | P-value |
| GOTERM_BP_FAT | GO:0007517-muscle organ development | 23 | 2.94×10−9 |
| GOTERM_BP_FAT | GO:0008285-negative regulation of cell proliferation | 27 | 2.35×10−7 |
| GOTERM_BP_FAT | GO:0007155-cell adhesion | 39 | 6.17×10−7 |
| GOTERM_BP_FAT | GO:0022610-biological adhesion | 39 | 6.27×10−7 |
| GOTERM_BP_FAT | GO:0003012-muscle system process | 16 | 7.10×10−6 |
| GOTERM_CC_FAT | GO:0044421-extracellular region part | 59 | 2.25×10−12 |
| GOTERM_CC_FAT | GO:0005576-extracellular region | 90 | 4.38×10−11 |
| GOTERM_CC_FAT | GO:0031012-extracellular matrix | 29 | 3.94×10−9 |
| GOTERM_CC_FAT | GO:0005578-proteinaceous extracellular matrix | 26 | 5.96×10−8 |
| GOTERM_CC_FAT | GO:0043292-contractile fiber | 16 | 8.23×10−8 |
| GOTERM_MF_FAT | GO:0046870-cadmium ion binding | 7 | 3.11×10−8 |
| GOTERM_MF_FAT | GO:0003779-actin binding | 27 | 5.32×10−8 |
| GOTERM_MF_FAT | GO:0008092-cytoskeletal protein binding | 34 | 9.74×10−8 |
| GOTERM_MF_FAT | GO:0005507-copper ion binding | 12 | 5.45×10−7 |
| GOTERM_MF_FAT | GO:0005198-structural molecule activity | 33 | 3.76×10−5 |
DEGs, differentially expressed genes; count, number of DEGs; BP, biological process; CC, cell component; MF, molecule function; ATP, adenosine 5′-phosphate; GO, Gene Ontology.