FIGURE 8.

p38 MAPK knockdown exacerbated INH-induced apoptosis. HepG2 cells were exposed to INH (60 mM) for 24 h after transfection with Silencer Negative Control siRNA (siCon) or p38 MAPK-siRNA (sip38), and the cleavages of caspase 9 (A) and caspase 3 (B) were detected by western blotting. Results are the representatives of at least three independent experiments, the upper parts of (A,B) indicate the representative blots of at least three independent experiments, respectively; the lower parts indicate the corresponding results of densitometric analyses of blots. Data are presented as mean ± SD of at least three independent experiments. procaspase 9, pro-Casp9; procaspase 3, pro-Casp3; cleaved caspase 9, c-Cas9; cleaved caspase 3, c-Cas3; ^∗∗P < 0.01.