Table 1.
Patient characteristics
| Healthy controls n = 32 | Primary TB n = 61 |
|
|---|---|---|
| Demographics | ||
| Age (years) | 30 (24–35) | 28 (22–43,5) |
| Male sex (n) | 25 (78%) | 44 (72%) |
| Smoker (n) | 8 (25%) | 30 (49%) |
| Affected family member with TB (n) | 0 (0%) | 6 (10%) |
| BCG-vaccinated (n) | 20 (63%) | 21 (34%) |
| HIV-positive (ii) | 0 (0%) | 2 (3%) |
| Symptoms | ||
| Fever (n) | 0 (0%) | 61 (100%) |
| Night sweats (n) | 0 (0%) | 23 (38%) |
| Weight loss (n) | 0 (0%) | 44 (72%) |
| Fatigue (n) | 1 (3%) | 32 (52%) |
| Shortness of breath (n) | 1 (3%) | 7 (11%) |
| Productive cough (n) | 3 (9%) | 56 (92%) |
| Signs | ||
| Temperature (°C) | 36.9 (36.5–37.1) | 37.2 (36.9–38.1)*** |
| MAP (mmHg) | 83 (79–93) | 80 (70–87)* |
| Heart rate (bpm) | 80 (78–84) | 90 (80–100)*** |
| Respiratory rate (brpm) | 20 (20–24) | 24 (22–28)*** |
| BMI (w/12) | 24.3 (22.7–26.0) | 17.6 (15.6–19.6)*** |
Abbreviations: BMI body mass index, expressed as weight (w) divided by length (l)2; bpm beats per minute, brpm breaths per minute, MAP mean arterial blood pressure, n total number, TB tuberculosis. Percentages given are within study group. Data are medians with interquartile ranges. *P < 0·05, ***P < 0·001 for the difference between primary TB or recurrent TB-patients versus controls