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. 2017 Oct 31;18:206. doi: 10.1186/s13059-017-1348-2

Fig. 5.

Fig. 5

Long noncoding RNAs (lncRNAs) in genome architecture. a The lncRNA Firre is transcribed from the X chromosome (chrX) and, by binding hnRNP-U, acts as a platform for trans-chromosomal interactions [107]. b The lncRNA NEAT1 functions as an essential structural determinant for the assembly of paraspeckles. The nucleation process begins during the biogenesis of the lncRNA, which acts as a scaffold for the binding of paraspeckle proteins and RNAs, including adenosine to inosine edited RNAs [111, 114]