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. 2017 Oct 30;24:83. doi: 10.1186/s12929-017-0388-y

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Expression of hypoxia marker HIF-1α associates with vitamin C level. (a) Analysis of ascorbic acid (AA), dehydroascorbic acid (DHAA) and both reduced and oxidized forms of ascorbate (TAA) levels in thyroid lesions (NG n = 51; FA n = 11; PC n = 23; FC n = 4). (b-e) Scatter plots showing HIF-1α (b), HIF-2α (c), hypoxia-related GLUT1 (d) and GLUT3 (e) proteins expression in relation to total vitamin C content in thyroid tumors (Spearman’s correlation). The median TAA value of 21,6 nmol/100 mg of tissue was used to classify sample as either ascorbate-deficient or ascorbate-replete. Ascorbate-deficient tumors had significantly higher levels of HIF-1 alpha protein than ascorbate-replete tumors (p < 0.01) by Mann-Whitney test