Table 3.

Numbers of microRNAs (out of the indicated numbers considered multimodal at each site) classified with respect to the tumor-normal test of differential expression as: (b, “blue”) overall significant, with significant directional agreement in one factor level and NS in the other; (g, “green”) overall NS, but significant in only one factor level; (o, “orange”) overall NS, and significant in opposite directions for factor levels; and (y, “yellow”) overall significant, with significant directional agreement in one factor level but significant in the opposite direction in the other factor level

	Proximal (of 122)				Distal (of 123)				Rectal (of 276)
Factor	b	g	o	y	b	g	o	y	b	g	o	y
MSI	27			1	62			1	186			4
CIMP	19			1	29				64	1
BRAF	13	3		1	58				176
TP53	16				10				28	5
KRAS	21	2			14				29	3	1
STAGE_D	32	1			12	1			53	2
STAGE_L	23				10				19	3	1
STAGE_R	19				15				21	1
AJCC_1	40	2			7	1			19	3
AJCC_2	18				10				16	2	1
AJCC_3	28	2			8	1			41	6
SEX	23	3			6				12	1
DIFF_NA	55				42
DIFF_WELL	37				30
DIFF_MOD	13				16
DIFF_POOR	21	1			27
VITAL_ALIVE	16				15	5			27	1
SURV5YRS	17				21	4	2		18	1
COD_CRC	19	1			3	6			67	9
ALCOHOL_reg	11				7				51	5
WINE_any	9	1			12	1			78	8	1	1
LIQUOR_any	13	1			14	3			68	5	1	1
BEER_any	16	2			11				56	2
CIG_ever	24	5			4				36	5
CIG_current	23				17	1			69	8	1
CIG_former	19	4			5				28	1
ESTROGEN	12	1			11				46	4
BMI_normal	9				10	2			33	4
BMI_overweight	17	4			10				30	1
BMI_obese	18				22				68	2
BMI_extreme	66				58				150	1