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. Author manuscript; available in PMC: 2017 Oct 31.
Published in final edited form as: Cell Metab. 2016 Aug 9;24(2):234–245. doi: 10.1016/j.cmet.2016.07.012

Figure 6. Relationship of the previously reported D314A variant with HDL-C.

Figure 6

A. Association of GALNT2 D314A with HDL-C in the MIExSeq rare variant association study (top) and the PROMIS study (bottom). For each association test, representative variants significantly associated with HDL-C for each respective study are given below the results for the GALNT2 D314A variant. Each study was 100% powered to detect a 1 S.D. change in HDL-C with significance level α=0.05. B. In vitro LPL activity in the presence of 0 µM ApoC-III, 20 µM total plasma ApoC-III, and 20 µM nonglycosylated ApoC-III. Data is shown as mean values ± S.D.. ****P<0.0001, Student’s unpaired T-test. C. Model for proposed targets of GALNT2 that modulate lipoprotein metabolism. Green lines show activating roles of GalNAc-T2 mediated O-glycosylation. Black dotted line indicates yet unclear regulatory effect of the glycosylation of indicated targets.