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. 2017 Oct 6;2(3):376–403. doi: 10.20411/pai.v2i3.218

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© Pathogens and Immunity 2017

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Figure 4. — The fatty acid composition of LPC is altered in HIV infection at baseline and week 48 compared to levels in HIV-uninfected participants and is associated with markers of immune activation. Plasma samples were thawed and the proportional representation (mol%) of A) SaFAs, MUFAs, and PUFAs and B) individual lipid molecules among the lysophosphatidylcholine lipid class were measured by the Complex Lipid Panel (Metabolon). Several changes in the proportional representation of SaFAs, MUFAs, and PUFAs were measured among samples from HIV- participants, and in samples from HIV+ participants pre-ART initiation (baseline) and following 48 weeks of ART. Mean levels are reported. C) Plasma and cryopreserved peripheral blood mononuclear cell (PBMC) samples were thawed and levels of immune activation were measured by ELISA or by flow cytometry. Pearson correlation values are reported for relationships among immune activation/disease progression markers and lipid levels. Statistically significant differences among the participant groups are designated; an exploratory value of P < 0.05 is used for a cutoff of significance. D) The fatty acid composition of LPC molecules is associated with levels of immune activation, including TNFR1. At 48 weeks, LPC molecules containing SaFAs (red) are directly related to levels of TNFR1; levels of PUFA containing LPC molecules (blue) are typically inversely related to TNFR1 levels.

Figure 4. — The fatty acid composition of LPC is altered in HIV infection at baseline and week 48 compared to levels in HIV-uninfected participants and is associated with markers of immune activation. Plasma samples were thawed and the proportional representation (mol%) of A) SaFAs, MUFAs, and PUFAs and B) individual lipid molecules among the lysophosphatidylcholine lipid class were measured by the Complex Lipid Panel (Metabolon). Several changes in the proportional representation of SaFAs, MUFAs, and PUFAs were measured among samples from HIV- participants, and in samples from HIV+ participants pre-ART initiation (baseline) and following 48 weeks of ART. Mean levels are reported. C) Plasma and cryopreserved peripheral blood mononuclear cell (PBMC) samples were thawed and levels of immune activation were measured by ELISA or by flow cytometry. Pearson correlation values are reported for relationships among immune activation/disease progression markers and lipid levels. Statistically significant differences among the participant groups are designated; an exploratory value of P < 0.05 is used for a cutoff of significance. D) The fatty acid composition of LPC molecules is associated with levels of immune activation, including TNFR1. At 48 weeks, LPC molecules containing SaFAs (red) are directly related to levels of TNFR1; levels of PUFA containing LPC molecules (blue) are typically inversely related to TNFR1 levels.