Supplemental Table 1A.
Supplemental Table 1. The concentration of total and free fatty acids is altered in HIV infection at baseline and week 48 compared to levels in HIV-uninfected donors. Plasma samples were thawed and the concentration (μM) of A) total and B) free (non-esterified) fatty acids were measured by the Complex Lipid Panel (Metabolon). Several changes in the concentrations of SaFAs, MUFAs, and PUFAs were measured among samples from HIV-uninfected participants, and in samples from HIV-infected individuals pre-ART initiation (baseline) and following 48 weeks of ART. Mean levels and standard deviations are reported. Statistically significant differences among the participant groups are designated in bold text; an exploratory value of P < 0.05 is used for a cutoff of significance.
| Type | Lipid Number | Common Name | HIV- (n = 13 |
HIV+ Baseline (n = 35) |
HIV+ Week 48 (n = 35) |
P values |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Concentraton (μM) | StD | Concentraton (μM) | StD | Concentraton (μM) | StD | HIV- v HIV+ Baseline | HIV- v HIV+ Week 48 | HIV + Baseline v Week 48 | |||
| SaFA | Total[FA12:0] | Lauric Acid | 16.12 | 7.46 | 33.96 | 33.54 | 39.77 | 55.93 | 0.0051 | 0.019 | 0.58 |
| SaFA | Total[FA14:0] | Myristc Acid | 170.22 | 84.34 | 198.50 | 123.33 | 215.48 | 175.26 | 0.37 | 0.24 | 0.46 |
| SaFA | Total[FA15:0] | Pentadecylic Acid | 36.04 | 14.00 | 41.64 | 23.95 | 41.30 | 29.86 | 0.32 | 0.33 | 0.86 |
| SaFA | Total[FA16:0] | Palmitc Acid | 2663.13 | 573.89 | 2654.08 | 924.25 | 2795.67 | 1153.88 | 0.97 | 0.60 | 0.31 |
| SaFA | Total[FA17:0] | Margaric Acid | 46.64 | 13.53 | 55.65 | 28.39 | 54.31 | 29.26 | 0.15 | 0.22 | 0.73 |
| SaFA | Total[FA18:0] | Stearic Acid | 722.38 | 163.34 | 714.94 | 218.48 | 711.97 | 241.36 | 0.90 | 0.87 | 0.93 |
| SaFA | Total[FA20:0] | Arachidic Acid | 65.11 | 92.69 | 34.50 | 11.57 | 36.40 | 12.10 | 0.26 | 0.29 | 0.24 |
| SaFA | Total[FA22:0] | Behenic Acid | 52.26 | 15.15 | 39.25 | 11.37 | 44.15 | 10.38 | 0.012 | 0.093 | 0.0074 |
| SaFA | Total[FA24:0] | Lignoceric Acid | 42.78 | 14.65 | 30.75 | 8.51 | 33.58 | 7.39 | 0.014 | 0.048 | 0.024 |
| SaFA | Total[FA26:0] | Cerotc Acid | 0.53 | 0.14 | 0.47 | 1.36 | 0.46 | 0.12 | 0.15 | 0.092 | 0.70 |
| MUFA | Total[FA14:1] | Myristoleic Acid | 11.75 | 5.62 | 15.48 | 11.81 | 15.87 | 13.73 | 0.15 | 0.15 | 0.85 |
| MUFA | Total[FA16:1] | Palmitoleic Acid | 283.65 | 102.04 | 313.76 | 197.72 | 320.79 | 205.12 | 0.50 | 0.41 | 0.81 |
| MUFA | Total[FA18:1] | Oleic Acid | 2357.10 | 502.91 | 2702.77 | 1136.79 | 2579.16 | 1121.12 | 0.15 | 0.35 | 0.39 |
| MUFA | Total[FA20:1] | Gondoic Acid | 26.10 | 10.59 | 25.30 | 12.57 | 22.96 | 7.73 | 0.83 | 0.34 | 0.096 |
| MUFA | Total[FA22:1] | Erucic Acid | 35.47 | 6.29 | 25.90 | 6.70 | 28.84 | 6.79 | 0.00013 | 0.0042 | 0.0029 |
| MUFA | Total[FA24:1] | Nervonic Acid | 75.46 | 12.42 | 61.58 | 17.97 | 64.74 | 15.70 | 0.0050 | 0.020 | 0.14 |
| MUFA | Total[FA26:1] | Hexacosanoic Acid | 0.95 | 0.21 | 0.75 | 0.22 | 0.78 | 0.22 | 0.0089 | 0.025 | 0.36 |
| PUFA | Total[FA18:2] | Linoleic Acid | 3763.40 | 871.88 | 3341.16 | 909.24 | 3390.61 | 834.08 | 0.15 | 0.20 | 0.67 |
| PUFA | Total[FA18:3] | α-Linolenic Acid | 163.59 | 38.41 | 169.58 | 2.99 | 174.45 | 94.37 | 0.75 | 0.57 | 0.74 |
| PUFA | Total[FA18:4] | Stearidonic Acid | 2.38 | 1.21 | 1.74 | 1.14 | 2.01 | 0.96 | 0.11 | 0.34 | 0.28 |
| PUFA | Total[FA20:2] | Eicosadienoic Acid | 20.73 | 4.25 | 24.78 | 10.61 | 23.61 | 8.70 | 0.065 | 0.13 | 0.38 |
| PUFA | Total[FA20:3] | Dihomo-γ-linolenic Acid | 138.54 | 33.48 | 142.23 | 55.31 | 148.12 | 60.14 | 0.78 | 0.49 | 0.52 |
| PUFA | Total[FA20:4] | Arachidonic Acid | 695.40 | 144.85 | 548.13 | 194.01 | 615.45 | 239.93 | 0.0082 | 0.17 | 0.015 |
| PUFA | Total[FA20:5] | Eicosapentanoic Acid | 60.60 | 16.62 | 44.03 | 28.05 | 61.12 | 35.16 | 0.017 | 0.95 | 0.0056 |
| PUFA | Total[FA22:2] | Docosadienoic Acid | 2.64 | 5.33 | 1.18 | 0.60 | 1.20 | 0.31 | 0.34 | 0.35 | 0.82 |
| PUFA | Total[FA22:4] | Docosatetraenoic Acid | 18.54 | 6.13 | 20.16 | 7.59 | 20.43 | 9.92 | 0.45 | 0.43 | 0.82 |
| PUFA | Total[FA22:5] | Docosapentaenoic Acid | 51.67 | 11.14 | 51.35 | 17.08 | 57.81 | 22.01 | 0.94 | 0.21 | 0.031 |
| PUFA | Total[FA22:6] | Docosahexaenoic Acid | 144.96 | 52.61 | 115.92 | 56.99 | 141.66 | 72.49 | 0.11 | 0.86 | 0.0045 |