Supplemental Table 3A.
Supplemental Table 3. The fatty acid composition and concentration of lysophosphatidylcholine (LPC) molecules is altered in HIV infection at baseline and week 48 compared to levels in HIV-uninfected donors. Plasma samples were thawed and A) the proportional representation (mol%) and B) concentration (μM) of LPC molecules were measured by the Complex Lipid Panel (Metabolon). Several changes in the proportional representation of SaFAs, MUFAs, and PUFAs were measured among samples from HIV- participants, and in samples from HIV+ participants pre-ART initiation (baseline) and following 48 weeks of ART. Mean levels and standard deviations are reported. Statistically significant differences among the participant groups are designated in bold text; an exploratory value of P < 0.05 is used for a cutoff of significance.
| Type | Lipid Number | Common Name | HIV- (n = 13) |
HIV+ Baseline (n = 35) |
HIV+ Week 48 (n = 35) |
P values |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Concentraton (μM) | StD | Concentraton (μM) | StD | Concentraton (μM) | StD | HIV- v HIV+ Baseline | HIV- v HIV+ Week 48 | HIV + Baseline v Week 48 | |||
| SaFA | LPC[FA12:0] | Lauric Acid | 0.010 | 0.012 | 0.0040 | 0.0020 | 0.0090 | 0.0040 | 0.39 | 0.87 | 0.089 |
| SaFA | LPC[FA14:0] | Myristc Acid | 0.12 | 0.060 | 0.15 | 0.11 | 0.19 | 0.089 | 0.18 | 0.0040 | 0.033 |
| SaFA | LPC[FA15:0] | Pentadecylic Acid | 0.49 | 0.17 | 0.65 | 0.33 | 0.70 | 0.31 | 0.035 | 0.0050 | 0.31 |
| SaFA | LPC[FA16:0] | Palmitc Acid | 87.90 | 25.46 | 111.83 | 40.27 | 120.95 | 36.46 | 0.020 | 0.0013 | 0.092 |
| SaFA | LPC[FA17:0] | Margaric Acid | 1.36 | 0.36 | 1.96 | 0.75 | 2.053 | 0.66 | 5.20E-04 | 3.46E-05 | 0.40 |
| SaFA | LPC[FA18:0] | Stearic Acid | 18.70 | 5.31 | 27.94 | 10.88 | 27.55 | 8.78 | 3.18E-04 | 1.53E-04 | 0.79 |
| SaFA | LPC[FA20:0] | Arachidic Acid | 0.056 | 0.016 | 0.070 | 0.026 | 0.061 | 0.022 | 0.034 | 0.36 | 0.086 |
| SaFA | LPC[FA22:0] | Behenic Acid | 0.0070 | 0.0040 | 0.0060 | 0.0030 | 0.0080 | 0.0040 | 0.45 | 0.92 | 0.17 |
| SaFA | LPC[FA24:0] | Lignoceric Acid | 0.0080 | 0.0030 | 0.0050 | 0.0020 | 0.0060 | 0.0050 | 0.057 | 0.40 | 0.20 |
| MUFA | LPC[FA14:1] | Myristoleic Acid | 0.0070 | 0.0060 | 0.0090 | 0.0050 | 0.0060 | 0.0030 | 0.54 | 0.70 | 0.14 |
| MUFA | LPC[FA16:1] | Palmitoleic Acid | 2.24 | 1.18 | 2.50 | 1.051 | 2.73 | 0.97 | 0.49 | 0.19 | 0.13 |
| MUFA | LPC[FA18:1] | Oleic Acid | 21.81 | 10.41 | 21.98 | 7.54 | 22.66 | 6.60 | 0.96 | 0.79 | 0.54 |
| MUFA | LPC[FA20:1] | Gondoic Acid | 0.14 | 0.043 | 0.19 | 0.077 | 0.19 | 0.070 | 0.0065 | 0.0062 | 0.87 |
| MUFA | LPC[FA22:1] | Erucic Acid | 0.010 | 0.007 | 0.0080 | 0.0060 | 0.0070 | 0.0050 | 0.62 | 0.50 | 0.75 |
| MUFA | LPC[FA24:1] | Nervonic Acid | 0.012 | 0.011 | 0.0070 | 0.0050 | 0.0050 | 0.0020 | 0.39 | 0.25 | 0.91 |
| PUFA | LPC[FA18:2] | Linoleic Acid | 37.076 | 16.42 | 27.15 | 10.29 | 28.81 | 9.44 | 0.059 | 0.11 | 0.33 |
| PUFA | LPC[FA18:3] | α-Linolenic Acid | 0.30 | 0.21 | 0.23 | 0.098 | 0.27 | 0.12 | 0.26 | 0.64 | 0.079 |
| PUFA | LPC[FA18:4] | Stearidonic Acid | 0.0060 | 0.0020 | 0.0070 | 0.006 | 0.0070 | 0.0040 | 0.63 | 0.52 | 0.24 |
| PUFA | LPC[FA20:2] | Eicosadienoic Acid | 0.34 | 0.18 | 0.39 | 0.15 | 0.35 | 0.15 | 0.41 | 0.81 | 0.23 |
| PUFA | LPC[FA20:3] | Dihomo-γ-linolenic Acid | 2.29 | 1.32 | 2.53 | 1.28 | 2.41 | 0.87 | 0.58 | 0.76 | 0.58 |
| PUFA | LPC[FA20:4] | Arachidonic Acid | 0.40 | 1.39 | 3.73 | 1.58 | 3.95 | 1.45 | 0.51 | 0.83 | 0.39 |
| PUFA | LPC[FA20:5] | Eicosapentanoic Acid | 0.15 | 0.055 | 0.115 | 0.085 | 0.150 | 0.083 | 0.12 | 0.96 | 0.061 |
| PUFA | LPC[FA22:2] | Docosadienoic Acid | 0.0070 | 0.0050 | 0.0060 | 0.0050 | 0.0080 | 0.0050 | 0.87 | 0.62 | 0.11 |
| PUFA | LPC[FA22:4] | Docosatetraenoic Acid | 0.066 | 0.040 | 0.093 | 0.059 | 0.080 | 0.052 | 0.075 | 0.31 | 0.30 |
| PUFA | LPC[FA22:5] | Docosapentaenoic Acid | 0.192 | 0.085 | 0.215 | 0.113 | 0.225 | 0.095 | 0.45 | 0.26 | 0.64 |
| PUFA | LPC[FA22:6] | Docosahexaenoic Acid | 0.29 | 0.12 | 0.27 | 0.14 | 0.32 | 0.16 | 0.58 | 0.49 | 0.099 |