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. Author manuscript; available in PMC: 2017 Oct 31.
Published in final edited form as: Nature. 2017 Mar 22;544(7648):105–109. doi: 10.1038/nature21706

Extended Data Figure 6. Characterization of platelets produced after lung transplantation.

Extended Data Figure 6

(a,b) Flow cytometric analysis of tomato+ platelets observed in the blood and stained with antibodies against CD41, CD42d, GPVI and c-Mpl. Blood from (a) PF4-tomato or (b) PF4-tomato→c-mpl-/- lung transplants. (c) Platelet activation experimental schema. (d) Flow cytometric analysis of tomato+ platelets after stimulation with thrombin (10 nM) and stained with antibody against CD62P. (e) Percentage of CD62P+ platelets before and after thrombin activation. Ctrl = PF4-tomato, Lung tx = PF4-tomato→c-mpl-/-. Mean ± SD are presented (n=2-3 mice per group). Unpaired t-test: **P < 0.01, ***P < 0.001