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. Author manuscript; available in PMC: 2017 Oct 31.
Published in final edited form as: Nature. 2017 Mar 22;544(7648):105–109. doi: 10.1038/nature21706

Extended Data Figure 9. Proposed schema of lung involvement in platelet biogenesis.

Extended Data Figure 9

The role of the lung in platelet biogenesis is two-fold and occurs in two different compartments. (a) Platelet production in the lung vasculature. After being released from the BM or the spleen, proplatelets (a1) and MKs (a2) are retained in the lung vasculature, the first capillary bed encountered by any cell leaving the BM, where proplatelet formation and extension and final platelet release is observed. (b) Presence of MKs and hematopoietic progenitors in the lung interstitium. Mature and immature MKs along with hematopoietic progenitors are found in the lung interstitium. In thrombocytopenic environments, hematopoietic progenitors from the lung migrate and restore BM hematopoietic deficiencies.