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. 2017 Oct 3;127(11):4104–4117. doi: 10.1172/JCI93437

Figure 10. Pair feeding reveals a more severe metabolic phenotype in Furinosb–/– mice.

Figure 10

Metabolic phenotyping of 4-month-old pair-fed Furinfl/fl (n = 12) and Furinosb–/– (n = 7) mice. (A) Body weight before initiation of pair feeding (week 0) and after 2 and 4 weeks of pair feeding. (B) Percentage of total fat mass over body weight after 4 weeks of pair feeding. (C) Fed blood glucose measurement after 3 weeks of pair feeding. (D) GTT results after 4 weeks of pair feeding. Mice were fasted for 16 hours and injected i.p. with 2 g/kg glucose. (E) ITT results after 4 weeks of pair feeding. Mice were fasted for 5 hours and injected i.p. with 0.3 U/kg of insulin. Results represent the mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001, by 2-way ANOVA for repeated measurements with Bonferroni’s multiple comparisons test (A, D, and E) or by unpaired, 2-tailed Student’s t test (B and C).