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. 2017 Oct 3;127(11):4104–4117. doi: 10.1172/JCI93437

Figure 9. Reduced energy expenditure and food intake in Furinosb–/– mice.

Figure 9

(A–E) Metabolic parameters of 6-month-old Furinfl/fl (n = 11) and Furinosb–/– (n = 9) mice. O2 consumption (A), CO2 release (B), heat production (energy expenditure) (C), and activity on the x axis (D) and y axis (E). (F) Epididymal fat pad weight normalized to the body weights of 12-month-old Furinfl/fl (n = 12) and Furinosb–/– (n = 12) mice fed a normal chow diet. (G–J) Food intake by 6-month-old Furinfl/fl (n = 11), Furinosb–/– (n = 9), Ocn+/+ (n = 8), and Ocn–/– (n = 8) mice. (G and I) Food intake during the light and dark periods. (H and J) Cumulative food intake over a 3-day period. Results represent the mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001, by 2-way ANOVA for repeated measurements with Bonferroni’s multiple comparisons test (A–E and G–J) or by unpaired, 2-tailed Student’s t test (F).