mRNA expression of Nppc, Npr3, and Npr2 in epiphyseal cartilage of tibiae, lumbar vertebrae, and blood vessels of 3- and 6-week-old WT mice. Data from tibial cartlilages and lumbar vertebrae were normalized to Hprt mRNA levels. Data from blood vessels were normalized to Gapdh mRNA levels. n = 4 each. **P < 0.01, by Student’s t test. Data are representative of at least 2 independent experiments.