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. 2017 Sep 25;127(11):3937–3953. doi: 10.1172/JCI92387

Figure 5. NPC transplantation impairs the production of polarizing cytokines by CNS-infiltrating APCs.

Figure 5

(A) Expression of Il23 and Tnf in CNS leukocytes isolated from EAE mice at 7 days after PBS or NPC treatment, relative value to PBS-treated mice (n = 3 mice per group). Data are representative of 2 independent experiments. (B) ELISA for IL23p19 in hindbrain and cervical and dorsal spinal cord tissues from PBS- and NPC-treated EAE mice obtained at the same time point as A (n = 3 mice per group). Data are representative of 2 independent experiments. (C) Cytokine profile in hindbrain tissues of PBS- and NPC-treated mice obtained at the same time point as A. Hindbrain tissue lysates were analyzed for expression of various cytokines by Luminex-based assay (n = 10 mice per group). Black bars, PBS-treated; white bars, NPC-treated. Data are mean ± SEM. *P ≤ 0.05, **P ≤ 0.01, unpaired t test.