Skip to main content
. 2017 Oct 3;127(11):4059–4074. doi: 10.1172/JCI94585

Figure 1. Fructose supplementation on HFD leads to higher weight gain and insulin resistance.

Figure 1

(A) Weight gain of mice on chow and HFD, supplemented with either regular, 30% fructose, or glucose-sweetened water for 10 weeks. (B) Liver weights of the same mice at sacrifice. (C) Percentage of visceral fat/total fat as measured by DEXA scan after 8 weeks on diet. (D) Blood glucose, (E) insulin levels and their calculated (F) HOMA-IR, measured after 8 weeks on diets. (G) Glucose tolerance test, (H) insulin tolerance test, and (I) glucose tolerance test calculated AUC measured after 8 weeks on diets. n = 7–8 mice per group. (J) Western blot analysis and ImageJ quantification of insulin signaling in the liver. F, fructose; G, glucose. n = 6 mice per group. Statistical analysis was performed using 2-way ANOVA with post hoc t tests between the individual groups. #P < 0.05; ##P < 0.01; ###P < 0.001; ####P < 0.0001, compared with Chow+H2O group. *P < 0.05; **P < 0.01; ***P < 0.001, within chow or HFD groups.