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. 2017 Oct 3;127(11):4059–4074. doi: 10.1172/JCI94585

Figure 5. KHK is induced with fructose supplementation and in patients with progressive liver disease.

Figure 5

(A) mRNA expression of Khk in the livers of mice at 10 weeks on different diets. n = 6 mice per group. Statistical analysis was performed using 2-way ANOVA with post hoc t tests between the individual groups. #P < 0.05; ##P < 0.01; ####P < 0.0001, compared with Chow+H2O group. ***P < 0.001; ****P < 0.0001, within chow or HFD groups. (B) KHK mRNA and protein levels in the livers of obese adolescent patients undergoing bariatric surgery. (C) mRNA expression of enzymes regulating fatty acid synthesis as well as (D) Western blot analysis and (E) ImageJ quantification of their protein levels. n = 4 subjects per group. Statistical analysis was performed using 1-way ANOVA. #P < 0.05; ##P < 0.01, compared with NoFL group. *P < 0.05, between steatosis and NASH groups.