Figure 7. Khk knockdown improves glucose tolerance.

Glucose tolerance in (A) HFD+Fruct and (B) HFD+H₂O and HFD+Gluc mice after 6 weeks on diets followed by 4 weeks of treatment with siRNA. (C) Western blot analysis and (D) ImageJ quantification of insulin signaling from livers of these mice. n = 6 mice per group. Statistical analysis was performed using 2-way ANOVA with post hoc t tests between the individual groups. *P < 0.05; **P < 0.01, between control and KHK RNAi–treated groups.