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Overexpression of Smad3 or suppression of Smad7 decreased the damage to CNE-2 cells after radiation. (A) the Smad3 overexpression vector and Smad7 suppression shRNA was transfected to CNE-2 cells successfully. (B) Smad3 mRNA expression was significantly increased in the Smad3 group but significantly decreased in the shSmad7 group. ** P < 0.01 vs. NC group. (C) compared with the NC+6 Gy group, the DNA damage was decreased in Smad3+6 Gy group and shSmad7+6 Gy group.
