Table 1. Demographic and clinical characteristics of HCV-infected patients register for OLT in the United States between 27-FEB-2002 and 30-JUN-2014.
| Patient characteristics | Overall population (N = 41,157) | Patients without HCC (N = 30,082) | Patients withHCC (N = 11,075) |
|---|---|---|---|
| Male sex, N(%) | 29,141 (70.8) | 20,518 (68.2) | 8,623 (77.9) |
| Age, mean ± SD | |||
| Male | 54.3 ± 6.9 | 53.2 ± 7.0 | 56.9 ± 6.2 |
| Female | 55.3 ± 7.8 | 54.5 ± 7.8 | 58.4 ± 7.0 |
| Race/Ethnicity, N(%) | |||
| White | 28,447 (69.1) | 21,220 (70.5) | 7,227 (65.3) |
| Black | 4,616 (11.2) | 3,215 (10.7) | 1,401 (12.7) |
| Hispanic | 6,365 (15.5) | 4,663 (15.5) | 1,702 (15.4) |
| Asian | 1,271 (3.1) | 662 (2.2) | 609 (5.5) |
| Other | 458 (1.1) | 322 (1.1) | 136 (1.2) |
| Lab-MELD, N(%) | |||
| MELD <10 | 7,640 (18.6) | 3,509 (11.7) | 4,131 (37.3) |
| MELD 10–14 | 14,271 (34.7) | 10,009 (33.3) | 4,262 (38.5) |
| MELD 15–19 | 9,450 (23.0) | 7,813 (26.0) | 1,637 (14.8) |
| MELD 20–24 | 4,629 (11.2) | 4,053 (13.5) | 576 (5.2) |
| MELD 25–29 | 2,014 (4.9) | 1,822 (6.1) | 192 (1.7) |
| MELD 30–34 | 1,325 (3.2) | 1,184 (3.9) | 141 (1.3) |
| MELD 35+ | 1,777 (4.3) | 1,650 (5.5) | 127 (1.1) |
| Missing | 51 (0.1) | 42 (0.1) | 9 (0.1) |
| Lab-MELD, mean± SD | 16.0 ± 7.9 | 17.3 ± 8.2 | 12.3 ± 5.9 |
| Allocation MELD, N(%) | |||
| MELD <10 | 7,547 (18.3) | 3,449 (11.5) | 4,098 (37.0) |
| MELD 10–14 | 14,076 (34.2) | 9,837 (32.7) | 4,239 (38.3) |
| MELD 15–19 | 9,330 (22.7) | 7,706 (25.6) | 1,624 (14.7) |
| MELD 20–24 | 4,586 (11.1) | 4,015 (13.3) | 571 (5.2) |
| MELD 25–29 | 1,982 (4.8) | 1,792 (6.0) | 190 (1.7) |
| MELD 30–34 | 1,315 (3.2) | 1,174 (3.9) | 141 (1.3) |
| MELD 35+ | 1,751 (4.3) | 1,626 (5.4) | 125 (1.1) |
| TemporarilyInactive | 570 (1.4) | 483 (1.6) | 87 (0.8) |
| BMI, mean ± SD | |||
| Male | 28.6 ± 5.0 | 28.7 ± 5.1 | 28.4 ± 4.7 |
| Female | 28.8 ± 6.0 | 28.8 ± 6.0 | 28.4 ± 5.7 |
| Laboratory values, mean ± SD | |||
| Albumin | 3.0 ±0.7 | 2.9 ±0.7 | 3.18 ±0.7 |
| Bilirubin | 4.2 ±7.0 | 4.8 ±7.7 | 2.39 ±4.1 |
| IRN | 1.5 ±0.8 | 1.6 ±0.9 | 1.33 ±0.4 |
| Serum creatinine | 1.3 ±1.2 | 1.4 ±1.3 | 1.03 ±0.8 |
| ABO blood type, N(%) | |||
| O | 19,218 (46.7) | 14,124 (47.0) | 5,094 (46.0) |
| A | 15,256 (37.1) | 11,138 (37.0) | 4,118 (37.2) |
| AB | 1,663 (4.0) | 1,217 (4.0) | 446 (4.0) |
| B | 5,020 (12.2) | 3,603 (12.0) | 1,417 (12.8) |
| Encephalopathy, N(%) | |||
| Absent | 16,341 (39.7) | 9,830 (32.7) | 6,511 (58.8) |
| Present | 24,759 (60.2) | 20,206 (67.2) | 4,553 (41.1) |
| Unknown | 57 (0.1) | 46 (0.2) | 11 (0.1) |
| Ascites, N(%) | |||
| Absent | 10,821 (26.3) | 5,637 (18.7) | 5,184 (46.8) |
| Present | 30,279 (73.6) | 24,399 (81.1) | 5,880 (53.1) |
| Unknown | 57 (0.1) | 46 (0.2) | 11 (0.1) |
| Diabetes, N(%) | |||
| No | 31,220 (75.9) | 22,897 (76.1) | 8,323 (75.2) |
| Yes | 9,393 (22.8) | 6,720 (22.3) | 2,673 (24.1) |
| Unknown | 544 (1.3) | 465 (1.5) | 79 (0.7) |
| Region, N (%)* | |||
| 1 | 1,813 (4.4) | 1,200 (4.0) | 613 (5.5) |
| 2 | 5,513 (13.4) | 4,072 (13.5) | 1,441 (13.0) |
| 3 | 5,218 (12.7) | 3,980 (13.2) | 1,238 (11.2) |
| 4 | 5,105 (12.4) | 3,912 (13.0) | 1,193 (10.8) |
| 5 | 8,061 (19.6) | 5,741 (19.1) | 2,320 (20.9) |
| 6 | 1,391 (3.4) | 927 (3.1) | 464 (4.2) |
| 7 | 2,428 (5.9) | 1,851 (6.2) | 577 (5.2) |
| 8 | 2,322 (5.6) | 1,673 (5.6) | 649 (5.9) |
| 9 | 3,343 (8.1) | 2,296 (7.6) | 1,047 (9.5) |
| 10 | 2,641 (6.4) | 1,894 (6.3) | 747 (6.7) |
| 11 | 3,322 (8.1) | 2,536 (8.4) | 786 (7.1) |
The database showed only very few missing values: 0.1% for encephalopathy, ascites and labMELD and 1.3% for diabetes at baseline.
*States and areas in regions of OPTN: 1 Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island, Vermont; 2 Delaware, District of Columbia,Maryland, New Jersey, Pennsylvania, Northern Virginia, West Virginia; 3 Alabama, Arkansas, Florida, Georgia, Louisiana, Mississippi, Puerto Rico 4 Oklahoma, Texas;5 Arizona, California, Nevada, New Mexico, Utah; 6 Alaska, Hawaii, Idaho, Montana, Oregon, Washington; 7 Illinois, Minnesota, North Dakota, South Dakota, Wisconsin;8 Colorado, Iowa, Kansas, Missouri, Nebraska, Wyoming; 9 New York; 10 Indiana, Michigan, Ohio; 11 Kentucky, North Carolina, South Carolina, Tennessee, Virginia.