TABLE 3.
Regression Coefficients Estimating Cognitive Function from Blood Pressure Variability Indices, Adjusted for Demographic Characteristics and Medical Conditions
| MMSE1 | Computer Assessment of Mild Cognitive Impairment2 | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Attention | Executive Function | Verbal Memory | Functional Memory | Incidental Memory | ||
| Systolic blood pressure | ||||||
|
| ||||||
| Range | 0.01 (0.02) | 0.18 (0.15) | 0.03 (0.13) | − 0.01 (0.19) | − 0.29 (0.17) | − 0.17 (0.14) |
| Standard deviation | 0 (0.04) | 0.31 (0.29) | 0.06 (0.23) | 0.04 (0.36) | − 0.61 (0.32) | − 0.32 (0.27) |
| Coefficient of variation | 0.02 (0.06) | 0.43 (0.43) | 0.06 (0.35) | − 0.23 (0.53) | − 0.92 (0.48) | − 0.59 (0.4) |
| Random slope | 0.07 (0.27) | 2.39 (1.92) | 0.04 (1.57) | 0.59 (2.41) | − 4.05 (2.15) | − 1.57 (1.80) |
|
| ||||||
| Diastolic blood pressure | ||||||
|
| ||||||
| Range | − 0.02 (0.04) | 0.07 (0.26) | − 0.23 (0.22) | − 0.62 (0.32) | − 0.26 (0.3) | − 0.58 (0.24)* |
| Standard deviation | − 0.05 (0.07) | 0.08 (0.5) | − 0.51 (0.4) | − 1.16 (0.61) | − 0.63 (0.56) | − 1.13 (0.45)* |
| Coefficient of variation | − 0.05 (0.05) | 0.02 (0.39) | − 0.39 (0.31) | − 1 (0.46)* | − 0.55 (0.43) | − 0.94 (0.35)† |
| Random slope | − 2.85 (3.93) | 3.91 (29.27) | − 26.26 (23.56) | − 65.68 (35.61) | − 29.42 (33.13) | − 58.97 (26.53)* |
*
P < 0.05.
†
P < 0.01.
Data are shown as regression coefficient (standard error).
We adjusted the results for age, sex, education level, and medical conditions (diabetes, hypercholesterolemia, obesity, and stroke). Regression diagnostics showed no violation of assumptions (including linearity, normality of residuals, homoscedasticity, influential observations, and collinearity) for any of the models.
MMSE = Mini-Mental State Examination.