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. Author manuscript; available in PMC: 2018 Mar 25.
Published in final edited form as: Nat Chem Biol. 2017 Sep 25;13(11):1195–1201. doi: 10.1038/nchembio.2475

Figure 1.

Figure 1

Structure of Corn-DFHO complex. (a) Chemical structures of DFHO and DFHBI (ref. 1,7). (b) Unbiased SAD experimental electron density map overlaid on refined Corn-DFHO structure. Blue and pink meshes correspond to 1.5σ and 4σ contours, respectively. (c) Sequence and secondary structure of Corn-DFHO. Thin lines denote connectivity and Leontis-Westhof symbols44 denote noncanonical base pairs. (d) Cartoon representation of the Corn-DFHO complex, color-coded as in (c). Purple and red spheres represent K+ ions and water molecules, respectively. (e) Cartoon representation of the A protomer of Corn RNA and DFHO, rotated 60° from (d).