Table 1.
miRNAs That Contribute to Hematopoiesis and Hematologic Malignancies
| MicroRNA | Role in Hematopoiesis | Role in Hematologic Malignancy | Known Targets |
|---|---|---|---|
| lin-4/miR-125 | Myelopoiesis | AML, MDS, ALL, DLBCL | BAK1, ST18, DICER1, BMF, KLF13 |
| let-7 | Megakaryopoiesis Granulopoiesis HSC differentiation |
LIN-28, HMGA2, RAS | |
| miR-15/miR-16 | Late erythroid differentiation | B-ALL, B-CLL, MCL, MM | BCL2, RARS, CCDN1, MCL1, CDK6 |
| miR-181 | B- and T-cell development Megakaryopoiesis Erythropoiesis |
AML, CLL | LIN-28, AID, BCL2 |
| miR-223 | Myelopoiesis Erythropoiesis Granulopoiesis B-Cell development |
CLL, ALL, AML, MALT | NFI-A, CEBPA, MEF2C, E2F1 |
| miR-155 | B- and T-cell development | DLBCL, BCL, AML | AID, SMAD5, INPP5D, HGAL, PU.1 |
| miR-146a | HSC maintenance Represses megakaryopoiesis and granulopoiesis |
MDS | CXCR4, TRAF6, IRAK1/2 |
| miR-17~92 | B-Cell development | BCL, CML, CLL, MCL, MM, FL | BIM, PTEN, E2F1, CCND1 |
| miR-21 | Myelopoiesis | CML, CLL, B-CLL, MDS, NK/T lymphoma | PTEN, PDCD4, SMAD7, MSH2, STAT3 |
| miR-22 | HSC maintenance | MDS, AML | TET1/2/3, PTEN |
| miR-203 | AML, CML, ALL, CLL, TCL | ABL1 | |
| miR-29 | HSC development and maintenance | B-CLL, CLL, AML, MCL | TCL1, MCL1, SP1, DNMT3B, HBP1 |
This table summarizes many of the miRNAs discussed in this review, their known roles in hematopoiesis and in hematologic malignancy, and a selection of their known targets. ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; BCL, B-cell lymphoma; CLL, chronic lymphoblastic leukemia; CML, chronic myeloid leukemia; DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; MALT, mucosa-associated lymphoid tissue lymphoma; MCL, mantle cell lymphoma; MDS, myelodysplastic syndrome; MM, multiple myeloma; TCL, T-cell lymphoma.