Figure 2. Dihydroorotase (PyrC) Structure-Based Sequence Alignment.
The PyrC sequence alignment from three clinically relevant bacterial species, S. aureus (SA), E. coli (EC), and B. anthracis (BA), is shown. Black boxes indicate the active site residues, defined as all residues within a five angstrom radius surrounding the active site zinc metals in the respective apo structures.