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. 2017 Oct 31;12(10):e0187348. doi: 10.1371/journal.pone.0187348

Fig 6. Immune function of MSCs in plate and collagen scaffold.

Fig 6

A) Schematic illustration of co-culture experiments. B) MSCs maintained in plates or collagen patches similarly suppressed the proliferation of CD4(+) lymphocytes. C) Induction of M2 macrophages by MSCs was reduced when MSCs were cultured in collagen patches and was absent in MSC-conditioned medium. D) The increase in IL10 secretion in macrophage/MSC co-cultures was less significant with MSCs cultured in patches, and was absent in monocytes cultured in MSC-conditioned medium. In all experiments n = 3 MSC donors. Error bars are SEM. * represents the statistical difference between groups. (*P <0.05; ** P <0.01; ***P <0.001).