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. 2017 Jul 6;8(48):83354–83369. doi: 10.18632/oncotarget.19042

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Copyright: © 2017 Jacamo et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A., IPA displaying the most significant Canonical Pathways associated with up-regulated genes induced by MLL/ENL leukemia in BM-MSC. The Stacked Bar Chart displays the up-regulated genes molecules in each Canonical Pathway with regards to their z-score. The color orange reflects a positive direction of change for the function. Z-scores ≥ 2 indicate that the function has a statistically significant increase. B., Examples of enrichment plots for the most significant enrichment sets for this dataset. Only enrichment sets with a normalized enrichment score (NES) ≥1.8 and ≤1.8 were considered as positive and negative associated respectively.